Takehiko SASAZUKI

笹月 健彦 (Takehiko SASAZUKI)

University Professor of Institute for Advanced Study, Kyushu University

Specialized Fields:
Immunogenetics

Pioneer research in Human Immunogenetics

Message

Strong international competition in recruiting young able people who have a full of curiosity and passion has been growing in intensity in the world. Because the world realized that the intellectual and technological innovation and development of human resources are essential to ensure the continuous development of human society with a high quality of culture and civilization for future.

I would like to dedicate my whole ability to the Institute for Advanced Study, which was newly established in Kyushu University, to be a place for new knowledge and technology development, and above all, a place for nurturing and sending out of outstanding young researchers.

Academic Background

March 1965

Faculty of Medicine, Kyushu University

March 1970

Graduate School, Faculty of Medicine, Tokyo Medical and Dental University(MD)

Occupation Background

April 1970

Research Associate of Tokyo Medical and Dental University

August 1973

Research Associate of Stanford University

August 1976

Associate Professor of Tokyo Medical and Dental University

June 1977

Professor of Tokyo Medical and Dental University

March 1983

Professor of Kyushu University

April 1990

Director of Medical Institute of Bioregulation, Kyushu University

April 2001

Director of the Research Institute of the National Center for Global Health and Medicine

April 2002

Professor Emeritus of Kyushu University

April 2004

President of the National Center for Global Health and Medicine

April 2008

President Emeritus of the National Center for Global Health and Medicine

October 2009

University Professor of Institute for Advanced Study, Kyushu University

Academic Awards・Awards

F.Y.1996

Paris Distinguished Service Award(France)

F.Y.1999

Japan Medical Association Medical Award

F.Y.2001

Takeda Medical Science Prize

F.Y.2002

Medal with Purple Ribbon

F.Y.2003

Rose Payne Distinguished Scientist Award(The U.S.A)

F.Y.2017

The Order of the Sacred Treasure, Gold and Silver Star

Research Project and Publication

I. Regulation of immune response by HLA

  • Fukui, Y., Hashimoto, O., Sanui, T., Oono, T., Koga, H., Abe, M., Inayoshi, A., Noda, M., Oike, M., Shirai T. & Sasazuki, T. Hematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature 412, 826-831 (2001).
  • Fukui, Y., Ishimoto, T., Utsuyama, M., Gyotoku, T., Koga, T., Nakao, K., Hirokawa, K., Katsuki, M. & Sasazuki, T. Positive and negative CD4+ thymocyte selection by a single MHC class Ⅱ/peptide ligand affected by its expression level in the thymus. Immunity 6, 401-410 (1997)
  • Hirayama, K., Matsushita, S., Kikuchi, I., Iuchi, M., Ohta, N. & Sasazuki, T. HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans. Nature 327, 426-430 (1987).
  • Nishimura, Y. & Sasazuki, T. Suppressor T cells control the HLA-linked low responsiveness to streprococcal antigen in man. Nature 301, 67-69 (1983).
  • Sasazuki, T., Kohno, Y., Iwamoto, I., Tanimura M & Naito, S. Association between an HLA haplotype and low responsiveness to tetanus toxoid in man. Nature 272, 359-361 (1978).

II. Control of autoimmune diseases and allergies by HLA

  • Sasazuki, T., Inoko, H., Morishima, S. & Morishima, Y. Gene Map of the HLA Region, Graves’ Disease and Hashimoto Thyroiditis, and Hematopoietic Stem Cell Transplantation. Adv immunol 129,175-249 (2016).
  • Ueda, S., Oryoji, D., Yamamoto, K., Noh, JY., Okamura, K., Noda, M., Kashiwase, K., Kosuga, Y., Sekiya, K., Inoue, K., Yamada, H., Oyamada, A., Nishimura, Y., Yoshikai, Y., Ito, K., & Sasazuki, T. Identification of independent susceptible and protective HLA alleles in Japanese autoimmune thyroid disease and their epistasis.
    J Clin Endocrinol Metab. 99, E379-83 (2014).
  • Uno, H., Sasazuki, T., Tamai, H. & Matsumoto, H. Two major genes, linked to HLA and Gm, control susceptibility to Graves’ disease. Nature 292, 768-770 (1981).

III. Graft versus host (GvH) disease caused by HLA mismatched combination in hematopoietic stem cell transplantation

  • Sasazuki, T., Juji, T., Morishima, Y., Kinukawa, N., Kashiwabara, H., Inoko, H., Yoshida, T., Kimura, A., Akaza, T., Kamikawaji, N., Kodera, Y. & Takaku, F. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. New Engl. J. Med. 339, 1177-1185 (1998)

IV. Recognition of HLA・peptide complex by T cell receptor(TCR)

  • Kusano, S., Kukimoto-Niino, M., Satta, Y., Ohsawa, N., Uchikubo-Kamo, T., Wakiyama, M., Ikeda, M., Terada, T., Yamamoto, K., Nishimura, Y., Shirouzu, M., Sasazuki, T. & Yokoyama, S. Structural basis for the specific recognition of the major antigenic peptide from the Japanese cedar pollen allergen Cry j 1 by HLA-DP5. J Mol Biol. 426, 3016-27 (2014) .

V. Molecular mechanisms of non-immune mediated monogenic disorders

  • Harada, F., Kimura, A., Iwanaga, T., Shimozawa, K., Yata, J. & Sasazuki, T. Gene conversion-like events cause steroid 21-hydroxylase deficiency in congenital adrenal hyperplasia. Proc. Natl. Acad. Sci. 84, 8091-8094 (1987) .

VI. Molecular mechanisms of carcinogenesis

  • Shirasawa, S., Furuse, M., Yokoyama, N. & Sasazuki, T. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 260, 85-88 (1993).