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KYUSYU UNIVERSITY

HOME > Organization・Members > Hiroyuki Sasaki

Organization・Members

Hiroyuki Sasaki, Dean of the Institute for Advanced Study
Name
Hiroyuki Sasaki
Year of Birth
1956
Occupancy
Kyushu University Senior Vice President, Dean of the Institute for Advanced Study
Academic Background
March, 1982
Bachelor of Medicine, School of Medicine, Kyushu University
March, 1987
PhD, Graduate School of Medical Science, Kyushu University
Occupation Background
April, 1990
British AFRC council fellow
November, 1992
University of Cambridge Wellcome/CRC Researcher
April, 1993
Research Institute of Balneotherapeutic Kyushu University Associate Professor
December,1998
National Institute of Genetics Department of Integrated Genetics Professor
April, 2004
Research Organization of Information and Systems National Institute of Genetics Department of Integrated Genetics Professor
January, 2010
Professor of Department of Molecular and Structural Biology
Medical Institute of Bioregulation
May, 2010
Kyushu University Distinguished Professor
April, 2011
Medical Institute of Bioregulation Vice Dean
April, 2011
Epigenome Network Research Center Director
April, 2012
Medical Institute of Bioregulation Dean
October, 2014
Kyushu University Senior Vice President
Academic Awards・Awards
F.Y.2009
The Japan Society of Human Genetics Award
F.Y.2012
The Genetic Society of Japan The Kihara Prize
F.Y.2015
The Medal with Purple Ribbon
Major Thesis
  • Maezawa, S., Hasegawa, K., Yukawa, M., Kubo, N., Sakashita, A., Alabattam, K.G., Sin, H.S., Kartashov, A.V., Sasaki, H., Barski, A. & Namekawa, S.H. Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline. Proc. Natl. Acad. Sci. USA (in press)
  • Okae, H., Toh, H., Sato, T., Hiura, H., Takahashi, S., Shirane, K., Kabayama, Y., Suyama, M., Sasaki, H. & Arima, T. Derivation of human trophoblast stem cells. Cell Stem Cell 22, 50-63 (2018)
  • Suzuki, A., Kawano, S., Mituyama, T., Suyama, M., Kanai, Y., Shirahige, K., Sasaki, H., Tokunaga, K., Tsuchihara, K., Sugano, S., Nakai, K. & Suzuki, Y. DBTSS/DBKERO for integrated analysis transcriptional regulation. Nucl. Acids Res. 46, D229-D238 (2018)
  • Maenohara, S., Unoki, M., Toh, H., Ohishi, H., Sharif, J., Koseki, H. & Sasaki, H. Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos. PLoS Genet. 13, e1007042. (2017)
  • Inoue, K., Ichiyanagi, K., Fukuda, K., Glinka, M. & Sasaki, H. Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice. PLoS Genet. 13, e1006926 (2017)
  • Sakata, Y., Nagao, K., Hoki, Y., Sasaki, H., Obuse, C. & Sado, T. Defects in dosage compensation impact global gene regulation in the mouse trophoblast. Development 144, 2784-2797 (2017)
  • Fukuda, K., Inoguchi, Y., Ichiyanagi, K., Ichiyanagi, T., Go, Y., Nagano, M., Yanagawa, Y., Takaesu, N., Ohkawa, Y., Imai, H. & Sasaki, H. Evolution of the sperm methylome of primates is associated with retrotransposon insertions and genome instability. Hum. Mol. Genet. 26, 3508-3519 (2017)
  • Ohta, H., Kurimoto, K., Okamoto, I., Nakamura, T., Yabuta, Y., Miyauchi, H., Yamamoto, T., Okuno, Y., Hagiwara, M., Shirane, K., Sasaki, H. & Saitou, M. In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate. EMBO J. 36, 1888-1907 (2017)
  • Kabayama, Y., Toh, H., Katanaya, A., Sakurai, T., Chuma, S., Kuramochi-Miyagawa, S., Saga, Y., Nakano, T. & Sasaki, H. Roles of MIWI, MILI and PLD6 in small RNA regulation in mouse growing oocytes. Nucl. Acids Res. 45, 5387-5398 (2017)
  • Kobayashi, M., Kato, H., Hada, H., Itoh-Nakadai, A,. Fujiwara, T., Muto, A,. Inoguchi, Y., Ichiyanagi, K., Houjou, W., Tomosugi, N., Sasaki, H., Harigae, H. & Igarashi, K. Iron-heme-Bachl axis is involved in erythroblast adaptation to iron deficiency. Haematologica 102, 454-465 (2017)
  • Ishikura, Y., Yabuta, Y., Ohta, H., Hayashi, K., Nakamura, T., Okamoto, I., Yamamoto, T., Kurimoto, K., Shirane, K., Sasaki, H. & Saitou, M. In vitro derivation and propagation of spermatogonial stem cell activity from mouse pluripotent stem cells. Cell Rep. 17, 2789-2804 (2016)
  • Hamada, H., Okae, H., Toh, H., Chiba, H., Hiura, H., Shirane, K., Sato, T., Suyama, M., Yaegashi, N., Sasaki, H. & Arima, T. Allele-specific methylome and transcriptome analysis reveals widespread imprinting in the human placenta. Am. J. Hum. Genet. 99, 1045-1058 (2016)
  • Shirane, K., Kurimoto, K., Yabuta, Y., Yamaji, M., Satoh, J., Ito, S., Watanabe, A., Hayashi, K., Saitou, M. & Sasaki, H. Global landscape and regulatory principles of DNA methylation reprogramming for germ cell specification by mouse pluripotent stem cells. Dev. Cell 39, 87-103 (2016)
  • Amouroux, R., Nashun, B., Shirane, K., Nakagawa, S., Hill, P.W., D'Souza, Z., Nakayama, M., Matsuda, M., Turp, A., Ndjetehe, E., Encheva, V., Kudo, N.R., Koseki, H., Sasaki, H. & Hajkova, P. De novo DNA methylation drives 5hmC accumulation in mouse zygotes. Nat. Cell Biol. 18, 225-233 (2016)
  • Amakawa, Y., Sakata, Y., Hoki, Y., Arata, S., Shioda, S., Fukagawa, T., Sasaki, H. & Sado, T. A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects. Development 142, 4299-4308 (2015)
  • Kubo, N., Toh, H., Shirane, K., Shirakawa, T., Kobayashi, H., Sato, T., Sone, H., Sato, Y., Tomizawa, S., Tsurusaki, Y., Shibata, H., Saitsu, H., Suzuki, Y., Matumoto, N., Suyama, M., Kono, T., Ohbo, K. & Sasaki, H. DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis. BMC Genomics 16, 624 (2015)
  • Thijssen, P.E., Ito, Y., Grillo, G., Wang, J., Velasco, G., Nitta, H., Unoki, M., Yoshihara, M., Suyama, M., Sun, Y., Lemmers, R.J.L.F., de Greef, J.C., Gennery, A., Picco, P., Kloeckener-Gruissem, B., Gungor, T., Reisli, I., Picard, C., Kebaili, K., Roquelaure, B., Iwai, T., Kondo, I., Kubota, T., van Ostaijen-Ten Dam, M.M., van Tol, M.J.D., Weemaes, C., Francastel, C., van der Maarel, S.M. & Sasaki. H. Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome. Nat. Commun. 6, 7870 (2015)
  • Ichiyanagi, T., Ichiyanagi, K., Ogawa, A., Kuramochi-Miyagawa, S., Nakano, T., Chuma, S., Sasaki, H. & Udono, H. HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse. Nucl. Acids Res. 42, 11903-11911 (2014)
  • Liu, S., Brind’Amour, J., Karimi, M.M., Shirane, K., Bogutz, A., Lefebvre, L., Sasaki, H., Shinkai, Y. & Lorincz, M.C. Setdb1 is required for germ line development and silencing of H3K9me3 marked endogenous retroviruses in primordial germ cells. Genes Dev. 28, 2041-2055 (2014)
  • Liao, H.-F., Chen, W.S.C., Chen, Y.-H., Kao, T.-H., Tseng, Y.-T., Lee, C.-Y., Chiu, Y.-C., Lee, P.-L., Lin, Q.-J., Ching, Y.-H., Hata, K., Cheng, W.T.K., Tsai, M.-H., Sasaki, H., Ho, H.-N., Wu, S.-C. , Huang, Y.-H., Yen, P. & Lin, S.-P. DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells. Development 141, 2402-2413 (2014)
  • Yokomizo, H., Inoguchi, T., Sonoda, N., Sakaki, Y., Maeda, Y., Inoue, T., Hirata, E., Takei, R., Ikeda, N., Fujii, M., Fukuda, K., Sasaki, H. & Takayanagi, R. Maternal high fat diet induces insulin resistance and deterioration of pancreatic β cell function in adult offspring with gender differences in mice. Am. J. Physiol. Endocrinol. Metab. 306, E1163-1175 (2014)
  • Okae, H., Matoba, S. Nagashima, T., Mizutani, E., Inoue, K., Ogonuki, N., Chiba, H., Funayama, R., Tanaka, S., Yaegashi, N., Nakayama, K., Sasaki, H., Ogura, A. & Arima, T. RNA sequencing-based identification of aberrant imprinting in cloned mice. Hum. Mol. Genet. 23, 992-1001 (2014)
  • Li, Y., Miyanari, Y., Shirane, K., Nitta, H., Kubota, T., Ohashi, H., Okamoto, A. & Sasaki, H. Sequence-specific microscopic visualization of DNA methylation status at satellite repeats in individual cell nuclei and chromosomes. Nucl. Acids Res. 41, e186 (2013)
  • Shirane, K., Toh, H., Kobayashi, H., Miura, F., Chiba, H., Ito, T., Kono, T. & Sasaki, H. Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases. PLoS Genet. 9, e1003439 (2013)
  • Unoki, M., Masuda, A., Dohmae, N., Arita, K., Yoshimatsu, M., Iwai, Y., Fukui, Y., Ueda, K., Hamamoto, R., Shirakawa, M., Sasaki, H. & Nakamura, Y. Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6). J. Biol. Chem. 288, 6053-6062 (2013)
  • Yamamoto, Y., Watanabe, T., Hoki, Y., Shirane, K., Li, Y., Ichiyanagi, K., Kuramochi-Miyagawa, S., Toyoda, A., Fujiyama, A., Oginuma, M., Suzuki, H., Sado, T., Nakano, T. & Sasaki, H. Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus. Genome Res. 23, 292-299 (2013)
  • Ichiyanagi, T., Ichiyanagi, K., Miyake, M. & Sasaki, H. Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development. Nucl. Acids Res. 41, 738-745 (2013)
  • Liu, Y., Toh, H., Sasaki, H., Zhang, X. & Cheng, X. An atomic model of ZFP57 recognition of CpG methylation within a specific DNA sequence. Genes Dev. 26, 2374-2379 (2012)
  • Okae, H., Hiura, H., Miyauchi, N., Abe, C., Nishida, Y., Funayama, R., Tanaka, S., Chiba, H., Yaegashi, N., Nakayama, K., Sasaki, H. & Arima, T. Re-investigation and RNA sequencing-based identification of genes with placenta-specific imprinted expression. Hum. Mol. Genet. 21, 548-558 (2012)
  • Ichiyanagi, K., Li, Y., Watanabe, T., Ichiyanagi, T., Fukuda, K., Kitayama, J., Yamamoto, Y., Kuramochi-Miyagawa, S., Nakano, T., Yabuta, Y., Seki, Y., Saitou, M. & Sasaki, H. Locus- and domain-dependent control of DNA methylation at mouse B1 retrotransposons during male germ cell development. Genome Res. 21, 2058-2066 (2011)
  • Watanabe, T., Tomizawa, S., Mitsuya, K., Totoki, Y., Yamamoto, Y., Kuramochi-Miyagawa, S., Iida, N., Hoki, Y., Murphy, P.J., Toyoda, A., Gotoh, K., Hiura, H., Arima, T., Fujiyama, A., Sado, T., Shibata, T., Nakano, T., Lin, H., Ichiyanagi, K., Soloway, P.D. & Sasaki, H. Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science 332, 848-852 (2011)
  • Hoki, Y., Ikeda, R., Mise, N., Sakata, Y., Ohhata, T., Sasaki, H., Abe, K. & Sado, T. Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse. Development 138, 2649-2659 (2011)
  • Watanabe, T., Chuma, S. Yamamoto, Y., Kuramochi-Miyagawa, S., Totoki, Y., Toyoda, A., Hoki, Y., Fujiyama, A., Shibata, T., Sado, T., Noce, T., Nakano, T., Nakatsuji, N., Lin, H. & Sasaki, H. MitoPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. Dev. Cell 20, 364-375 (2011)
  • Tomizawa, S., Kobayashi, H., Watanabe, T., Andrews, S., Hata, K., Kelsey, G. & Sasaki, H. Dynamic stage-specific changes of imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes. Development 128, 811-820 (2011)
  • Borgel, J., Guibert, S., Li, Y., Chiba, H., Schuebeler, D., Sasaki, H., Forne, T. & Weber, M. Targets and dynamics of promoter DNA methylation during early mouse development. Nat. Genet. 42, 1093-1100 (2010)
  • Hiura, H., Sugawara, A., Ogawa, H., John, R., Miyauchi, N., Miyanari, Y., Horiike, T., Li, Y., Yaegashi, N., Sasaki, H., Kono, T. & Arima, T. A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucl. Acids Res. 38, 4929-4945 (2010)
  • Kuramochi-Miyagawa, S., Watanabe, T., Gotoh, K., Takamatsu, K., Chuma, S., Kojima-Kita, K., Shiromoto, Y., Asada, N., Kimura, T., Nakatsuji, N., Noce, T., Sasaki, H. & Nakano, T. MVH in piRNA processing and gene silencing of retrotransposons. Genes Dev. 24, 887-892 (2010)
  • Shoji, M., Tanaka, T., Hosokawa, M., Reuter, M., Stark, A., Kato, Y., Kondoh, G., Okawa, K., Chujo, T., Suzuki, T., Hata, K., Martin, S.L., Noce, T., Kuramochi-Miyagawa, S., Nakano, T., Sasaki, H., Pillai, R.S., Nakatsuji, N. & Chuma, S. The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev. Cell 17, 745-746 (2009)
  • Yamaguchi, S., Kurimoto, K., Yabuta, Y., Sasaki, H., Nakatsuji, N., Saitou, M. & Tada, T. Conditional knockdown of Nanog induces apoptotic cell death in mouse migrating primordial germ cells. Development 136, 4011-4020 (2009)
  • Hoki, Y., Kimura, N., Kanbayashi, M., Ohhata, T., Amakawa, Y., Sasaki, H. & Sado, T. A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse. Development 136, 139-146 (2009)
  • Hu, Y.-G., Hirasawa, R., Hu, J.-L., Hata, K., Jin, Y., Chen, T., Li, E., Rigolet, M., Viegas-Pequignot, E., Sasaki, H. & Xu, G.-L. Regulation of DNA methylation activity through DNMT3L promoter methylation by DNMT3 enzymes in embryonic development. Hum. Mol. Genet. 17, 2654-2664 (2008)
  • Hirasawa, R., Chiba, H., Kaneda, M., Tajima, S., Li, E., Jaenisch, R. & Sasaki, H. Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev. 22, 1607-1616 (2008)
  • Watanabe, T., Totoki, Y., Toyoda, A., Kaneda, M., Kuramochi-Miyagawa, S., Obata, Y., Chiba, H., Kohara, Y., Kono, T., Nakano, T., Surani, M.A., Sakaki, Y. & Sasaki, H. Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature 453, 539-543 (2008)
  • Kuramochi-Miyagawa, S., Watanabe, T., Gotoh, K., Totoki, Y., Toyoda, A., Ikawa, M., Asada, N., Kojima, K., Yamaguchi, Y., Ijiri, T., Hata, K., Li, E., Matsuda, Y., Kimura, T., Okabe, M., Sakaki, Y., Sasaki, H. & Nakano, T. DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev. 22, 908-917 (2008)
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