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HOME > 組織・メンバー > 佐々木 裕之
佐々木 裕之 (Hiroyuki Sasaki) ささき ひろゆき
氏  名
佐々木 裕之 (Hiroyuki Sasaki)
生年月日
昭和31年
現  職
九州大学副学長
九州大学高等研究院長
学歴
昭和57年 3月
九州大学医学部医学科修了
昭和62年 3月
九州大学大学院医学研究科博士課程修了
職歴
平成 2年  4月
英国ケンブリッジAFRC動物生理学遺伝学研究所研究員
平成 4年 11月
英国ケンブリッジWellcome/CRC研究所研究員
平成 5年  4月
九州大学遺伝情報実験施設助教授
平成10年12月
国立遺伝学研究所総合遺伝研究系教授
平成16年  4月
情報・システム研究機構国立遺伝学研究所総合遺伝研究系教授
平成22年  1月
九州大学生体防御医学研究所分子機能制御学部門教授
平成22年  5月
九州大学主幹教授
平成23年  4月
九州大学生体防御医学研究所副所長
平成23年  4月
九州大学エピゲノムネットワーク研究センター長
平成24年  4月
九州大学生体防御医学研究所長
平成26年10月
九州大学副学長
平成30年  4月
九州大学高等研究院長
学術賞・受章
平成21年
日本人類遺伝学会賞
平成24年
日本遺伝学会 木原賞
平成27年
紫綬褒章
最近の主要論文
  • Maezawa, S., Hasegawa, K., Yukawa, M., Kubo, N., Sakashita, A., Alabattam, K.G., Sin, H.S., Kartashov, A.V., Sasaki, H., Barski, A. & Namekawa, S.H. Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline. Proc. Natl. Acad. Sci. USA (in press)
  • Okae, H., Toh, H., Sato, T., Hiura, H., Takahashi, S., Shirane, K., Kabayama, Y., Suyama, M., Sasaki, H. & Arima, T. Derivation of human trophoblast stem cells. Cell Stem Cell 22, 50-63 (2018)
  • Suzuki, A., Kawano, S., Mituyama, T., Suyama, M., Kanai, Y., Shirahige, K., Sasaki, H., Tokunaga, K., Tsuchihara, K., Sugano, S., Nakai, K. & Suzuki, Y. DBTSS/DBKERO for integrated analysis transcriptional regulation. Nucl. Acids Res. 46, D229-D238 (2018)
  • Maenohara, S., Unoki, M., Toh, H., Ohishi, H., Sharif, J., Koseki, H. & Sasaki, H. Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos. PLoS Genet. 13, e1007042. (2017)
  • Inoue, K., Ichiyanagi, K., Fukuda, K., Glinka, M. & Sasaki, H. Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice. PLoS Genet. 13, e1006926 (2017)
  • Sakata, Y., Nagao, K., Hoki, Y., Sasaki, H., Obuse, C. & Sado, T. Defects in dosage compensation impact global gene regulation in the mouse trophoblast. Development 144, 2784-2797 (2017)
  • Fukuda, K., Inoguchi, Y., Ichiyanagi, K., Ichiyanagi, T., Go, Y., Nagano, M., Yanagawa, Y., Takaesu, N., Ohkawa, Y., Imai, H. & Sasaki, H. Evolution of the sperm methylome of primates is associated with retrotransposon insertions and genome instability. Hum. Mol. Genet. 26, 3508-3519 (2017)
  • Ohta, H., Kurimoto, K., Okamoto, I., Nakamura, T., Yabuta, Y., Miyauchi, H., Yamamoto, T., Okuno, Y., Hagiwara, M., Shirane, K., Sasaki, H. & Saitou, M. In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate. EMBO J. 36, 1888-1907 (2017)
  • Kabayama, Y., Toh, H., Katanaya, A., Sakurai, T., Chuma, S., Kuramochi-Miyagawa, S., Saga, Y., Nakano, T. & Sasaki, H. Roles of MIWI, MILI and PLD6 in small RNA regulation in mouse growing oocytes. Nucl. Acids Res. 45, 5387-5398 (2017)
  • Kobayashi, M., Kato, H., Hada, H., Itoh-Nakadai, A,. Fujiwara, T., Muto, A,. Inoguchi, Y., Ichiyanagi, K., Houjou, W., Tomosugi, N., Sasaki, H., Harigae, H. & Igarashi, K. Iron-heme-Bachl axis is involved in erythroblast adaptation to iron deficiency. Haematologica 102, 454-465 (2017)
  • Ishikura, Y., Yabuta, Y., Ohta, H., Hayashi, K., Nakamura, T., Okamoto, I., Yamamoto, T., Kurimoto, K., Shirane, K., Sasaki, H. & Saitou, M. In vitro derivation and propagation of spermatogonial stem cell activity from mouse pluripotent stem cells. Cell Rep. 17, 2789-2804 (2016)
  • Hamada, H., Okae, H., Toh, H., Chiba, H., Hiura, H., Shirane, K., Sato, T., Suyama, M., Yaegashi, N., Sasaki, H. & Arima, T. Allele-specific methylome and transcriptome analysis reveals widespread imprinting in the human placenta. Am. J. Hum. Genet. 99, 1045-1058 (2016)
  • Shirane, K., Kurimoto, K., Yabuta, Y., Yamaji, M., Satoh, J., Ito, S., Watanabe, A., Hayashi, K., Saitou, M. & Sasaki, H. Global landscape and regulatory principles of DNA methylation reprogramming for germ cell specification by mouse pluripotent stem cells. Dev. Cell 39, 87-103 (2016)
  • Amouroux, R., Nashun, B., Shirane, K., Nakagawa, S., Hill, P.W., D'Souza, Z., Nakayama, M., Matsuda, M., Turp, A., Ndjetehe, E., Encheva, V., Kudo, N.R., Koseki, H., Sasaki, H. & Hajkova, P. De novo DNA methylation drives 5hmC accumulation in mouse zygotes. Nat. Cell Biol. 18, 225-233 (2016)
  • Amakawa, Y., Sakata, Y., Hoki, Y., Arata, S., Shioda, S., Fukagawa, T., Sasaki, H. & Sado, T. A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects. Development 142, 4299-4308 (2015)
  • Kubo, N., Toh, H., Shirane, K., Shirakawa, T., Kobayashi, H., Sato, T., Sone, H., Sato, Y., Tomizawa, S., Tsurusaki, Y., Shibata, H., Saitsu, H., Suzuki, Y., Matumoto, N., Suyama, M., Kono, T., Ohbo, K. & Sasaki, H. DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis. BMC Genomics 16, 624 (2015)
  • Thijssen, P.E., Ito, Y., Grillo, G., Wang, J., Velasco, G., Nitta, H., Unoki, M., Yoshihara, M., Suyama, M., Sun, Y., Lemmers, R.J.L.F., de Greef, J.C., Gennery, A., Picco, P., Kloeckener-Gruissem, B., Gungor, T., Reisli, I., Picard, C., Kebaili, K., Roquelaure, B., Iwai, T., Kondo, I., Kubota, T., van Ostaijen-Ten Dam, M.M., van Tol, M.J.D., Weemaes, C., Francastel, C., van der Maarel, S.M. & Sasaki. H. Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome. Nat. Commun. 6, 7870 (2015)
  • Ichiyanagi, T., Ichiyanagi, K., Ogawa, A., Kuramochi-Miyagawa, S., Nakano, T., Chuma, S., Sasaki, H. & Udono, H. HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse. Nucl. Acids Res. 42, 11903-11911 (2014)
  • Liu, S., Brind’Amour, J., Karimi, M.M., Shirane, K., Bogutz, A., Lefebvre, L., Sasaki, H., Shinkai, Y. & Lorincz, M.C. Setdb1 is required for germ line development and silencing of H3K9me3 marked endogenous retroviruses in primordial germ cells. Genes Dev. 28, 2041-2055 (2014)
  • Liao, H.-F., Chen, W.S.C., Chen, Y.-H., Kao, T.-H., Tseng, Y.-T., Lee, C.-Y., Chiu, Y.-C., Lee, P.-L., Lin, Q.-J., Ching, Y.-H., Hata, K., Cheng, W.T.K., Tsai, M.-H., Sasaki, H., Ho, H.-N., Wu, S.-C. , Huang, Y.-H., Yen, P. & Lin, S.-P. DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells. Development 141, 2402-2413 (2014)
  • Yokomizo, H., Inoguchi, T., Sonoda, N., Sakaki, Y., Maeda, Y., Inoue, T., Hirata, E., Takei, R., Ikeda, N., Fujii, M., Fukuda, K., Sasaki, H. & Takayanagi, R. Maternal high fat diet induces insulin resistance and deterioration of pancreatic β cell function in adult offspring with gender differences in mice. Am. J. Physiol. Endocrinol. Metab. 306, E1163-1175 (2014)
  • Okae, H., Matoba, S. Nagashima, T., Mizutani, E., Inoue, K., Ogonuki, N., Chiba, H., Funayama, R., Tanaka, S., Yaegashi, N., Nakayama, K., Sasaki, H., Ogura, A. & Arima, T. RNA sequencing-based identification of aberrant imprinting in cloned mice. Hum. Mol. Genet. 23, 992-1001 (2014)
  • Li, Y., Miyanari, Y., Shirane, K., Nitta, H., Kubota, T., Ohashi, H., Okamoto, A. & Sasaki, H. Sequence-specific microscopic visualization of DNA methylation status at satellite repeats in individual cell nuclei and chromosomes. Nucl. Acids Res. 41, e186 (2013)
  • Shirane, K., Toh, H., Kobayashi, H., Miura, F., Chiba, H., Ito, T., Kono, T. & Sasaki, H. Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases. PLoS Genet. 9, e1003439 (2013)
  • Unoki, M., Masuda, A., Dohmae, N., Arita, K., Yoshimatsu, M., Iwai, Y., Fukui, Y., Ueda, K., Hamamoto, R., Shirakawa, M., Sasaki, H. & Nakamura, Y. Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6). J. Biol. Chem. 288, 6053-6062 (2013)
  • Yamamoto, Y., Watanabe, T., Hoki, Y., Shirane, K., Li, Y., Ichiyanagi, K., Kuramochi-Miyagawa, S., Toyoda, A., Fujiyama, A., Oginuma, M., Suzuki, H., Sado, T., Nakano, T. & Sasaki, H. Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus. Genome Res. 23, 292-299 (2013)
  • Ichiyanagi, T., Ichiyanagi, K., Miyake, M. & Sasaki, H. Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development. Nucl. Acids Res. 41, 738-745 (2013)
  • Liu, Y., Toh, H., Sasaki, H., Zhang, X. & Cheng, X. An atomic model of ZFP57 recognition of CpG methylation within a specific DNA sequence. Genes Dev. 26, 2374-2379 (2012)
  • Okae, H., Hiura, H., Miyauchi, N., Abe, C., Nishida, Y., Funayama, R., Tanaka, S., Chiba, H., Yaegashi, N., Nakayama, K., Sasaki, H. & Arima, T. Re-investigation and RNA sequencing-based identification of genes with placenta-specific imprinted expression. Hum. Mol. Genet. 21, 548-558 (2012)
  • Ichiyanagi, K., Li, Y., Watanabe, T., Ichiyanagi, T., Fukuda, K., Kitayama, J., Yamamoto, Y., Kuramochi-Miyagawa, S., Nakano, T., Yabuta, Y., Seki, Y., Saitou, M. & Sasaki, H. Locus- and domain-dependent control of DNA methylation at mouse B1 retrotransposons during male germ cell development. Genome Res. 21, 2058-2066 (2011)
  • Watanabe, T., Tomizawa, S., Mitsuya, K., Totoki, Y., Yamamoto, Y., Kuramochi-Miyagawa, S., Iida, N., Hoki, Y., Murphy, P.J., Toyoda, A., Gotoh, K., Hiura, H., Arima, T., Fujiyama, A., Sado, T., Shibata, T., Nakano, T., Lin, H., Ichiyanagi, K., Soloway, P.D. & Sasaki, H. Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science 332, 848-852 (2011)
  • Hoki, Y., Ikeda, R., Mise, N., Sakata, Y., Ohhata, T., Sasaki, H., Abe, K. & Sado, T. Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse. Development 138, 2649-2659 (2011)
  • Watanabe, T., Chuma, S. Yamamoto, Y., Kuramochi-Miyagawa, S., Totoki, Y., Toyoda, A., Hoki, Y., Fujiyama, A., Shibata, T., Sado, T., Noce, T., Nakano, T., Nakatsuji, N., Lin, H. & Sasaki, H. MitoPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline. Dev. Cell 20, 364-375 (2011)
  • Tomizawa, S., Kobayashi, H., Watanabe, T., Andrews, S., Hata, K., Kelsey, G. & Sasaki, H. Dynamic stage-specific changes of imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes. Development 128, 811-820 (2011)
  • Borgel, J., Guibert, S., Li, Y., Chiba, H., Schuebeler, D., Sasaki, H., Forne, T. & Weber, M. Targets and dynamics of promoter DNA methylation during early mouse development. Nat. Genet. 42, 1093-1100 (2010)
  • Hiura, H., Sugawara, A., Ogawa, H., John, R., Miyauchi, N., Miyanari, Y., Horiike, T., Li, Y., Yaegashi, N., Sasaki, H., Kono, T. & Arima, T. A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucl. Acids Res. 38, 4929-4945 (2010)
  • Kuramochi-Miyagawa, S., Watanabe, T., Gotoh, K., Takamatsu, K., Chuma, S., Kojima-Kita, K., Shiromoto, Y., Asada, N., Kimura, T., Nakatsuji, N., Noce, T., Sasaki, H. & Nakano, T. MVH in piRNA processing and gene silencing of retrotransposons. Genes Dev. 24, 887-892 (2010)
  • Shoji, M., Tanaka, T., Hosokawa, M., Reuter, M., Stark, A., Kato, Y., Kondoh, G., Okawa, K., Chujo, T., Suzuki, T., Hata, K., Martin, S.L., Noce, T., Kuramochi-Miyagawa, S., Nakano, T., Sasaki, H., Pillai, R.S., Nakatsuji, N. & Chuma, S. The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev. Cell 17, 745-746 (2009)
  • Yamaguchi, S., Kurimoto, K., Yabuta, Y., Sasaki, H., Nakatsuji, N., Saitou, M. & Tada, T. Conditional knockdown of Nanog induces apoptotic cell death in mouse migrating primordial germ cells. Development 136, 4011-4020 (2009)
  • Hoki, Y., Kimura, N., Kanbayashi, M., Ohhata, T., Amakawa, Y., Sasaki, H. & Sado, T. A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse. Development 136, 139-146 (2009)
  • Hu, Y.-G., Hirasawa, R., Hu, J.-L., Hata, K., Jin, Y., Chen, T., Li, E., Rigolet, M., Viegas-Pequignot, E., Sasaki, H. & Xu, G.-L. Regulation of DNA methylation activity through DNMT3L promoter methylation by DNMT3 enzymes in embryonic development. Hum. Mol. Genet. 17, 2654-2664 (2008)
  • Hirasawa, R., Chiba, H., Kaneda, M., Tajima, S., Li, E., Jaenisch, R. & Sasaki, H. Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev. 22, 1607-1616 (2008)
  • Watanabe, T., Totoki, Y., Toyoda, A., Kaneda, M., Kuramochi-Miyagawa, S., Obata, Y., Chiba, H., Kohara, Y., Kono, T., Nakano, T., Surani, M.A., Sakaki, Y. & Sasaki, H. Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature 453, 539-543 (2008)
  • Kuramochi-Miyagawa, S., Watanabe, T., Gotoh, K., Totoki, Y., Toyoda, A., Ikawa, M., Asada, N., Kojima, K., Yamaguchi, Y., Ijiri, T., Hata, K., Li, E., Matsuda, Y., Kimura, T., Okabe, M., Sakaki, Y., Sasaki, H. & Nakano, T. DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev. 22, 908-917 (2008)
業績(著書等)
  • 「エピジェネティクス(Springer Reviews シリーズ)」佐々木裕之編
  • 「エピジェネティクス入門 -三毛猫の模様はどう決まるのか-(岩波科学ライブラリー)」佐々木裕之著
  • 「Genomic Imprinting」Editors: Hiroyuki Sasaki and Fumitoshi Ishino
www.ias.kyushu-u.ac.jp
6-10-1 HAKOZAKI, HIGASHI-KU, FUKUOKA, 812-8581, JAPAN
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