INOUE Kazuhide

University Professor of Institute for Advanced Study, Kyushu University

Specialized Fields : Neuropharmacology,
Neurochemistry

Microglia and Intractable Chronic Pain
The roles of ATP receptors

Message

In order for Kyushu University to become a truly international research and education center in this remote area of Japan, Fukuoka, we must have world-class research capabilities and a diversity education system with research backbone. Especially, we deeply need the human resources to achieve that. The mission of the Institute for Advanced Studies is to become an incubator that raises such human resources under the name of “Kyushu University Renaissance Project”, and to present the concept with high ideals in a long span for the research and education scenes that are likely to fall into a short-sighted perspective.

While I was performing my duties at the university headquarters, I continued to seek such a high-ranking ideal function from the Institute for Advanced Studies, but I did not expect myself to be a member of the Institute as a University Professor. I would like to approach the ideal function step by step while asking myself whether I am enough to be a member of the Institute for Advanced Study.

Academic Background

March 1973

School of Pharmaceutical Sciences , Kyushu University

March 1975

Graduate School of Pharmaceutical Sciences, Kyushu University

July 1985

Ph.D

Occupation Background

April 1978

The Ministry of Health and Welfare, Department of Pharmacology, Center for Biological Safety and Research, National Institute of Health Sciences

August 1985 ~ September 1987

Visiting fellow, National Institutes of Health, USA

March 1991 ~ February 1992

Honorary Research Fellow, University College London

October 2002

Division Head of Metabolism Biochemistry, National Institute of Health Sciences

January 2005

Professor of Graduate School of Pharmaceutical Science, Kyushu University

May 2009

Distinguished Professor, Kyushu University

April 2010 ~ March 2014

Dean of Graduate School of Pharmaceutical Science, Kyushu University

October 2014 ~ September 2020

Executive Vice-President, Kyushu University

October 2020

University Professor of Institute for Advanced Study, Kyushu University

Academic Awards・Awards

F.Y. 2007

Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology

F.Y. 2010

Ebashi Setsuro Award, The Japanese Pharmacological Society
Medal from His Majesty the Spanish Emperor as an honor of lifelong foreign member of Royal Academy of Pharmacy

F.Y. 2013

The Pharmaceutical Society of Japan Award

F.Y. 2014

The Medal with Purple Ribbon

Publication List

  1. M. Tsuda, Y. Shigemoto-Mogami, S. Koizumi, A. Mizokoshi、, S. Kohsaka, M. W. Salter and K. Inoue. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424, 778-783, 2003
  2. J.A.M. Coull, S. Beggs, D. Boudreau, D. Boivin, M. Tsuda, K. Inoue, C.Gravel, M.W. Salter and Y. De Koninck. BDNF from microglia mediates the shift in neuronal anion gradient that underlies neuropathic pain. Nature 438, 1017-1021, 2005
  3. S. Koizumi, Y. Shigemoto-Mogami, K. Nasu-Tada, Y. Shinozaki, K. Ohsawa, M. Tsuda, B.V. Joshi, K.A. Jacobson, S. Kohsaka, K. Inoue. UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature 446, 1091-1095, 2007
  4. Nakaya M, et al. GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance. Nat Commun. 4:1532, 2013
  5. T. Masuda, S. Iwamoto, R. Yoshinaga, H. Tozaki-Saitoh A. Nishiyama, T. W. Mak, T. Tamura, M. Tsuda, K. Inoue. Transcription factor IRF5 drives P2X4R+ reactive microglia gating neuropathic pain. Nat Commun. 5:3771, 2014
  6. M. Shiratori-Hayashi, K. Koga, H. Tozaki-Saitoh, Y. Kohro, H. Toyonaga, C. Yamaguchi, A. Hasegawa, T. Nakahara, J. Hachisuka, S. Akira, H. Okano, M. Furue, K. Inoue & M. Tsuda. STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch.Nat Med. 21:927-31, 2015
  1. S. Koyanagi, N. Kusunose, M. Taniguchi, T. Akamine, Y. Kanado, Y. Ozono, T. Masuda, Y. Kohro, N. Matsunaga, M. Tsuda, M. Salter, K. Inoue, and S. Ohdo. Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia. Nat Commun. 7:13102, 2016
  2. Hayashi Y, Morinaga S, Zhang J, Satoh Y, Meredith AL, Nakata T, Wu Z, Kohsaka S, Inoue K, Nakanishi H. BK channels in microglia are required for morphine-induced hyperalgesia. Nat Commun. 7:11697, 2016
  3. T. Masuda, Y. Ozono, S. Mikuriya, Y. Kohro, H. Tozaki-Saitoh, K. Iwatsuki, H. Uneyama, R. Ichikawa, M. W. Salter, M. Tsuda, K. Inoue. Dorsal horn neurons release extracellular ATP in neuropathic pain in a VNUT-dependent manner. Nat Commun. 7:12529, 2016
  4. Inoue K, Tsuda M. Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential. Nature Rev Neurosci 19(3):138-152, 2018
  5. Y. Kohro, T. Matsuda, K. Yoshihara, K. Kohno, K. Koga, R. Katsuragi, T. Oka, R. Tashima, S. Muneta, T. Yamane, S. Okada, K. Momokino, A. Furusho, K. Hamase, T. Oti, H. Sakamoto, K. Hayashida, R. Kobayashi, T. Horii, I. Hatada, H. Tozaki-Saitoh, K. Mikoshiba, V. Taylor, K. Inoue, M. Tsuda. Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity. Nat Neurosci. 23(11):1376-1387, 2020