Member
University Professor
SASAKI Hiroyuki
University Professor of Institute for Advanced Study, Kyushu University
Specialized Fields
Molecular Biology, Genetics, Epigenetics, Developmental Biology
Pioneering research on the molecular mechanisms of epigenetics
Message
In order to overcome the current situation where globalization and fragmentation of society are simultaneously progressing and global-scale issues are piling up, it is necessary to gather the wisdom of humanity and to cooperate with other countries around the world. Under these circumstances, I believe Kyushu University plays a very important role as it is located in Fukuoka, the center of East Asia which has always been a point of contact between Japan and the continent.On this occasion, I have the fortuitous opportunity to join the Institute for Advanced Study, where I once served as Dean, as a University Professor. I hope I can be of some help in fostering young researchers who have a global perspective, value intellectual curiosity, and continue to take on new challenges. I will practice “Open mind, creative spirit” together with you and we would like to realize a center for academic research and higher education that accomplish ‘‘ leap into the next ”.
Academic Background
- March 1982
- Faculty of Medicine, Kyushu University
- March 1987
- Graduate School of Medicine, Kyushu University（Ph.D.）
Occupation Background
- June 1982
- Resident, Kyushu University Hospital
- April 1986
- JSPS Research Fellow
- May 1987
- Assistant Professor of Research Laboratory of Genetic Information, Kyushu University
- April 1990
- Overseas Research Fellow of AFRC Institute of Animal Physiology and Genetics, University of Cambridge, UK
- November 1992
- Overseas Research Fellow of Welcome/CRC Institute, University of Cambridge, UK
- April 1993
- Associate Professor, Institute of Genetic Information, Kyushu University
- December 1998
- Professor of Department of Integrated Genetics, National Institute of Genetics
- April 1999
- Head of Department of Integrated Genetics, National Institute of Genetics
- April 2004
- Professor of National Institute of Genetics, Research Organization of Information and Systems
- January 2010
- Professor of Medical Institute of Bioregulation, Kyushu University
- May 2010
- Distinguished Professor, Kyushu University
- April 2012
- Director of Medical Institute of Bioregulation, Kyushu University
- April 2014
- Vice President, Kyushu University
- April 2018
- Dean of Institute for Advanced Study, Kyushu University
- April 2022
- University Professor of Institute for Advanced Study, Kyushu University
Academic Awards・Awards
- F.Y. 1997
- Japanese Society of Human Genetics, Encouragement Award
- F.Y.2009
- Society of Human Genetics, Society Award
- F.Y.2012
- Genetics Society of Japan – Kihara Award
- F.Y.2015
- Purple Ribbon Medal
- F.Y.2019
- Uehara Prize
Publication List
- Sasaki H, et al. (1985年). “Presymptomatic diagnosis of heterozygosity for familial amyloidotic polyneuropathy by recombinant DNA techniques”. Lancet 325: 100.
- Ferguson-Smith AC, et al. (1993). “Parental-origin-specific epigenetic modification of the mouse H19 gene”. Nature 362: 751-755.
- Kaneda M, et al. (2004). “Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting”. Nature 429: 900-903.
- Watanabe T, et al. (2008). “Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes”. Nature 453:539-543.
- Sasaki H and Matsui Y. (2008). “Epigenetic events in mammalian germ-cell development: reprogramming and beyond”. Nat. Rev. Genet. 9:129-140.
- Watanabe T, et al. (2011). “Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus”. Science 332:848-852.
- Stunnenberg HG, et al. (2016年). “The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery”. Cell 167: 1145-1149.
- Yamashiro C, et al. (2018). “Generation of human oogonia from induced pluripotent stem cells in vitro”. Science 362: 356-360.
- Tucci V, et al. (2019). “Genomic imprinting and physiological processes in mammals”. Cell 176: 952-965.
- Ishiuchi T, et al. (2021). “Reprogramming of the histone H3.3 landscape in the early mouse embryo“. Nat. Struct. Mol. Biol. 28: 38-49.